Product Datasheet  
BAP1 Antibody  
Catalog Number: 36226  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q92560
    NCBI Gene ID: 8314
    Gene Accssion: BC001596
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Fusion protein corresponding to a region derived from internal residues of human BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Western blotting: 1:500-1:2000
    Immunohistochemistry: 1:150-1:300

  • other_names：  
  • UCHL2; hucep-6; HUCEP-13
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total BAP1 protein.
  • Applications：  
  • WB IHC
  • Background：  

  • This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma




 
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