SETD2 Antibody

Catalog Number:

36150

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9BYW2
NCBI Gene ID: 29072
Gene Accssion: BC117162

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human SET domain containing 2

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SETD2 protein.

Applications:

IHC

Background:

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.

References:

appl_detail:

Immunohistochemistry: 1:50-1:200

Datasheet PDF