Product Datasheet  
SETD2 Antibody  
Catalog Number: 36150  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q9BYW2
    NCBI Gene ID: 29072
    Gene Accssion: BC117162
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Fusion protein corresponding to residues near the C terminal of human SET domain containing 2
  • reactivity：  
  • Hu
  • appl_detail：  
  • Immunohistochemistry: 1:50-1:200
  • other_names：  
  • HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP
  • Purification：  
  • Antigen affinity purification.
  • Specificity：  
  • The antibody detects endogenous levels of total SETD2 protein.
  • Applications：  
  • IHC
  • Background：  
  • Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.



 
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