FLIP Antibody

Catalog Number:

35423

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:O15519;
NCBI Gene#:8837

Form of Antibody:

Rabbit IgG in 1XPBS, 40% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region within amino acids 418 and 480 of FLIP.

Purification:

Antibodies were purified by antigen-affinity chromatography.

Specificity/Sensitivity:

The antibody detects endogenous levels of total FLIP protein.

Applications:

WB

Background:

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

References:

appl_detail:

Western blotting: 1:500-1:3000

Datasheet PDF