Cytochrome C Antibody

Catalog Number:

21680

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P99999
Gene ID:54205

Form of Antibody:

Storage/Stability:

Immunogen:

Peptide sequence around aa.71-75(N-P-K-K-Y) derived from Human Cytochrome C.

Purification:

Specificity/Sensitivity:

The antibody detects endogenous level of total Cytochrome C protein.

Applications:

WB

Background:

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

References:

appl_detail:

Predicted MW: 14kd
Western blotting: 1: 500~1: 1000

Datasheet PDF