MAGEC2 Antibody

Catalog Number:

35279

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9UBF1
NCBI Gene ID: 51438

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human MAGEC2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MAGEC2 protein.

Applications:

WB

Background:

Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.

Gure A.O., Int. J. Cancer 85:726-732(2000) [PubMed: 10699956].
Lucas S., Int. J. Cancer 87:55-60(2000) [PubMed: 10861452].
Wang Y., J. Immunol. 169:1102-1109(2002) [PubMed: 12097419].

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF