Product Datasheet  
MAGEC2 Antibody  
Catalog Number: 35279  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9UBF1
    NCBI Gene ID: 51438
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human MAGEC2.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • Cancer/testis antigen 10; CT10; HCA587; hepatocellular cancer antigen 587; Hepatocellular carcinoma-associated antigen 587
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total MAGEC2 protein.
  • Applications：  
  • WB
  • Background：  
  • Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.

    Gure A.O., Int. J. Cancer 85:726-732(2000) [PubMed: 10699956].
    Lucas S., Int. J. Cancer 87:55-60(2000) [PubMed: 10861452].
    Wang Y., J. Immunol. 169:1102-1109(2002) [PubMed: 12097419].



 
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