SIRT3 Antibody

Catalog Number:

35202

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9NTG7
NCBI Gene ID: 23410

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from C-terminal of human SIRT3.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SIRT3 protein.

Applications:

WB

Background:

NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.

Bechtel S., BMC Genomics 8:399-399(2007).
Schwer B., J. Cell Biol. 158:647-657(2002).
Onyango P., Proc. Natl. Acad. Sci. U.S.A. 99:13653-13658(2002).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF