CREB3L2 Antibody

Catalog Number:

35185

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q70SY1
NCBI Gene ID: 64764

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human CREB3L2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CREB3L2 protein.

Applications:

WB

Background:

Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage By similarity.

Storlazzi C.T., Hum. Mol. Genet. 12:2349-2358(2003).
Ota T., Nat. Genet. 36:40-45(2004).
Scherer S.W., Science 300:767-772(2003).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF