HSPA8 Antibody

Catalog Number:

35220

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P11142
NCBI Gene ID: 3312

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human HSPA8.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total HSPA8 protein.

Applications:

WB

Background:

Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Muraki T., Mol. Pharmacol. 58:1257-1263(2000).
Quadroni M., Submitted (MAR-2009).
Keith W.N., Submitted (JAN-2010).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF