Product Datasheet  
HSPA8 Antibody  
Catalog Number: 35220  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P11142
    NCBI Gene ID: 3312
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human HSPA8.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Western blotting: 1:500~1:3000

  • other_names：  
  • LAP-1
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total HSPA8 protein.
  • Applications：  
  • WB
  • Background：  

  • Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

    Muraki T., Mol. Pharmacol. 58:1257-1263(2000).
    Quadroni M., Submitted (MAR-2009).
    Keith W.N., Submitted (JAN-2010).




 
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