CHML Antibody

Catalog Number:

34948

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P26374
NCBI Gene ID: 1122

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human CHML.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total CHML protein.

Applications:

WB IHC

Background:

Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.

Cremers F.P.M., Hum. Mol. Genet. 1:71-75(1992).
Kasper G., Gene 295:27-32(2002).
Ota T. Nat. Genet. 36:40-45(2004)

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF