MBTPS2 Antibody

Catalog Number:	34784
other_names:	Membrane-bound transcription factor site-2 protease; EC 3.4.24.85; S2P endopeptidase; Site-2 protease; Sterol regulatory element-binding proteins intramembrane protease
Amount:	100μg
calculated_mw:
host_species:	Rabbit
Price:	$319
Swiss-Prot No:	Swiss-Prot: O43462 NCBI Gene ID: 51360
Form of Antibody:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage/Stability:
Immunogen:	Synthesized peptide derived from internal of human MBTPS2.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity/Sensitivity:	The antibody detects endogenous levels of total MBTPS2 protein.
Applications:	IF
Background:	Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop. Rawson R.B., Mol. Cell 1:47-57(1997). Ye J., Proc. Natl. Acad. Sci. U.S.A. 97:5123-5128(2000).
References:
appl_detail:	Immunofluorescence: 1:100~1:500
	Datasheet PDF

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