Product Datasheet  
MBTPS2 Antibody  
Catalog Number: 34784  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: O43462
    NCBI Gene ID: 51360
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human MBTPS2.
  • reactivity：  
  • Hu
  • appl_detail：  


  • Immunofluorescence: 1:100~1:500
  • other_names：  
  • Membrane-bound transcription factor site-2 protease; EC 3.4.24.85; S2P endopeptidase; Site-2 protease; Sterol regulatory element-binding proteins intramembrane protease
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total MBTPS2 protein.
  • Applications：  
  • IF
  • Background：  
  • Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.

    Rawson R.B., Mol. Cell 1:47-57(1997).
    Ye J., Proc. Natl. Acad. Sci. U.S.A. 97:5123-5128(2000).




 
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