FOLR1 Antibody

Catalog Number:

34683

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P15328
NCBI Gene ID: 2348

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human FOLR1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total FOLR1 protein.

Applications:

WB IHC IF

Background:

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.

Elwood P.C., J. Biol. Chem. 264:14893-14901(1989).
Lacey S.W., J. Clin. Invest. 84:715-720(1989).
Campbell I.G., Cancer Res. 51:5329-5338(1991).

References:

appl_detail:

Western blotting: 1:500~1:3000

IF 1:100-1:500

IHC 1:50-1:200

Datasheet PDF