Product Datasheet  
FOLR1 Antibody  
Catalog Number: 34683  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P15328
    NCBI Gene ID: 2348
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human FOLR1.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Western blotting: 1:500~1:3000

    IF 1:100-1:500

    IHC 1:50-1:200

  • other_names：  
  • Folate receptor alpha; FR-alpha; Folate receptor 1; Folate receptor; adult
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total FOLR1 protein.
  • Applications：  
  • WB IHC IF
  • Background：  

  • Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.

    Elwood P.C., J. Biol. Chem. 264:14893-14901(1989).
    Lacey S.W., J. Clin. Invest. 84:715-720(1989).
    Campbell I.G., Cancer Res. 51:5329-5338(1991).




 
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