MAN1B1 Antibody

Catalog Number:

34675

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9UKM7
NCBI Gene ID: 11253

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human MAN1B1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MAN1B1 protein.

Applications:

WB

Background:

Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man5-6GlcNAc2.

Tremblay L.O., Glycobiology 9:1073-1078(1999) [PubMed: 10521544].
Gonzalez D.S., J. Biol. Chem. 274:21375-21386(1999) [PubMed: 10409699].
Clark H.F., Genome Res. 13:2265-2270(2003) [PubMed: 12975309].

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF