Product Datasheet  
MAN1B1 Antibody  
Catalog Number: 34675  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9UKM7
    NCBI Gene ID: 11253
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human MAN1B1.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • Endoplasmic reticulum mannosyl-oligosaccharide 1; 2-alpha-mannosidase; EC=3.2.1.113; ER alpha-1; 2-mannosidase
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total MAN1B1 protein.
  • Applications：  
  • WB
  • Background：  
  • Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man5-6GlcNAc2.

    Tremblay L.O., Glycobiology 9:1073-1078(1999) [PubMed: 10521544].
    Gonzalez D.S., J. Biol. Chem. 274:21375-21386(1999) [PubMed: 10409699].
    Clark H.F., Genome Res. 13:2265-2270(2003) [PubMed: 12975309].




 
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