RNF138 Antibody

Catalog Number:	34663
other_names:	E3 ubiquitin-protein ligase RNF138; EC 6.3.2.-; RING finger protein 138; Nemo-like kinase-associated RING finger protein; NLK-associated RING finger protein
Amount:	100μg
calculated_mw:
host_species:	Rabbit
Price:	$319
Swiss-Prot No:	Swiss-Prot: Q8WVD3 NCBI Gene ID: 51444
Form of Antibody:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage/Stability:
Immunogen:	Synthesized peptide derived from internal of human RNF138.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity/Sensitivity:	The antibody detects endogenous levels of total RNF138 protein.
Applications:	WB
Background:	E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. Wang L., Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. Ota T., Nat. Genet. 36:40-45(2004). Kalnine N., Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
References:
appl_detail:	Western blotting: 1:500~1:3000
	Datasheet PDF

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