MARCH4 Antibody

Catalog Number:

34661

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9P2E8
NCBI Gene ID: 57574

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human MARCH4.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MARCH4 protein.

Applications:

IHC

Background:

E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Nagase T., DNA Res. 7:65-73(2000).
The MGC Project Team; Genome Res. 14:2121-2127(2004).
Bartee E., J. Virol. 78:1109-1120(2004).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF