Product Datasheet  
MARCH4 Antibody  
Catalog Number: 34661  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9P2E8
    NCBI Gene ID: 57574
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human MARCH4.
  • reactivity：  
  • Hu Ms
  • appl_detail：  


  • Immunohistochemistry: 1:50~1:100

  • other_names：  
  • E3 ubiquitin-protein ligase MARCH4 ; EC 6.3.2.-; Membrane-associated RING finger protein 4; Membrane-associated RING-CH protein IV; MARCH-IV
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total MARCH4 protein.
  • Applications：  
  • IHC
  • Background：  

  • E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

    Nagase T., DNA Res. 7:65-73(2000).
    The MGC Project Team; Genome Res. 14:2121-2127(2004).
    Bartee E., J. Virol. 78:1109-1120(2004).




 
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