DOCK1 Antibody

Catalog Number:

34642

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q14185
NCBI Gene ID: 1793

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human DOCK1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total DOCK1 protein.

Applications:

WB

Background:

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.

Hasegawa H., Mol. Cell. Biol. 16:1770-1776(1996).
Deloukas P., Nature 429:375-381(2004).
Matsuda M., J. Biol. Chem. 271:14468-14472(1996).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF