Product Datasheet  
DOCK1 Antibody  
Catalog Number: 34642  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q14185
    NCBI Gene ID: 1793
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human DOCK1.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • 180 kDa protein downstream of CRK; dedicator of cytokinesis protein 1; DOC1; DOCK180;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total DOCK1 protein.
  • Applications：  
  • WB
  • Background：  
  • Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.

    Hasegawa H., Mol. Cell. Biol. 16:1770-1776(1996).
    Deloukas P., Nature 429:375-381(2004).
    Matsuda M., J. Biol. Chem. 271:14468-14472(1996).



 
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