HSD11B1 Antibody

Catalog Number:

34623

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P28845
NCBI Gene ID: 3290

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from N-terminal of human HSD11B1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total HSD11B1 protein.

Applications:

WB IHC

Background:

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol By similarity.

Tannin G.M., J. Biol. Chem. 266:16653-16658(1991).
Draper N., J. Clin. Endocrinol. Metab. 87:4984-4990(2002).
Ota T., Nat. Genet. 36:40-45(2004) .

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF