Product Datasheet  
HSD11B1 Antibody  
Catalog Number: 34623  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P28845
    NCBI Gene ID: 3290
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from N-terminal of human HSD11B1.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • Corticosteroid 11-beta-dehydrogenase isozyme 1; 11-DH; 11-beta-hydroxysteroid;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total HSD11B1 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol By similarity.

    Tannin G.M., J. Biol. Chem. 266:16653-16658(1991).
    Draper N., J. Clin. Endocrinol. Metab. 87:4984-4990(2002).
    Ota T., Nat. Genet. 36:40-45(2004) .



 
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