Cytochrome P450 2A6 Antibody

Catalog Number:

34232

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P11509
NCBI Gene ID: 1548

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from N-terminal of human Cytochrome P450 2A6.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Cytochrome P450 2A6 protein.

Applications:

WB

Background:

Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.

Miles J.S., ic Acids Res. 17:2907-2917(1989).
Yamano S., Biochemistry 29:1322-1329(1990).
Saito S., J. Hum. Genet. 48:249-270(2003).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF