Cytochrome P450 24A1 Antibody

Catalog Number:

34229

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q07973
NCBI Gene ID: 1591

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human Cytochrome P450 24A1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Cytochrome P450 24A1 protein.

Applications:

WB

Background:

Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D3) and calcitriol (1-alpha,25-dihydroxyvitamin D3). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.

Chen K.-S., Proc. Natl. Acad. Sci. U.S.A. 90:4543-4547(1993).
Deloukas P., Nature 414:865-871(2001).
Chen K.-S., Biochim. Biophys. Acta 1263:1-9(1995).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF