Product Datasheet  
Cytochrome P450 24A1 Antibody  
Catalog Number: 34229  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q07973
    NCBI Gene ID: 1591
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human Cytochrome P450 24A1.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • 1,25-dihydroxyvitamin D; 24- hydroxylase; 24-OHase; 24-hydroxylase
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Cytochrome P450 24A1 protein.
  • Applications：  
  • WB
  • Background：  
  • Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D3) and calcitriol (1-alpha,25-dihydroxyvitamin D3). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.

    Chen K.-S., Proc. Natl. Acad. Sci. U.S.A. 90:4543-4547(1993).
    Deloukas P., Nature 414:865-871(2001).
    Chen K.-S., Biochim. Biophys. Acta 1263:1-9(1995).





 
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