Cofilin Antibody

Catalog Number:

34215

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P23528/Q9Y281
NCBI Gene ID: 1073/1072

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human Cofilin.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Cofilin protein.

Applications:

WB

Background:

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.

Thirion C., Eur. J. Biochem. 268:3473-3482(2001).
Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005).
Olsen J.V., Cell 127:635-648(2006).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF