Product Datasheet  
Cofilin Antibody  
Catalog Number: 34215  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P23528/Q9Y281
    NCBI Gene ID: 1073/1072
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human Cofilin.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • CFL2; COF2; Cofilin 2; Cofilin; muscle isoform
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Cofilin protein.
  • Applications：  
  • WB
  • Background：  
  • Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.

    Thirion C., Eur. J. Biochem. 268:3473-3482(2001).
    Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005).
    Olsen J.V., Cell 127:635-648(2006).




 
© Signalway Biotechnology All Rights Reserved.