GIT1 Antibody

Catalog Number:

34131

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9Y2X7
NCBI Gene ID: 28964

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from C-terminal of human GIT1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total GIT1 protein.

Applications:

WB IHC

Background:

GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes.

Premont R.T., J. Biol. Chem. 275:22373-22380(2000).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Premont R.T., Proc. Natl. Acad. Sci. U.S.A. 95:14082-14087(1998).

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF