Product Datasheet  
GIT1 Antibody  
Catalog Number: 34131  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9Y2X7
    NCBI Gene ID: 28964
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from C-terminal of human GIT1.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • ARF GTPase-activating protein GIT1; G protein-coupled receptor kinase- interactor 1; similar to G protein-coupled receptor kinase-interactor 1; G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total GIT1 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes.

    Premont R.T., J. Biol. Chem. 275:22373-22380(2000).
    The MGC Project Team, Genome Res. 14:2121-2127(2004).
    Premont R.T., Proc. Natl. Acad. Sci. U.S.A. 95:14082-14087(1998).



 
© Signalway Biotechnology All Rights Reserved.