RHG07 Antibody

Catalog Number:

34035

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q96QB1
NCBI Gene ID: 10395

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human RHG07.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total RHG07 protein.

Applications:

IHC IF

Background:

Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.

Yuan B.Z., Cancer Res. 58:2196-2199(1998).
Nagase T., DNA Res. 7:347-355(2000).
Wilson P.J., Hum. Mutat. 15:156-165(2000).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Datasheet PDF