Product Datasheet  
RHG07 Antibody  
Catalog Number: 34035  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q96QB1
    NCBI Gene ID: 10395
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human RHG07.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunohistochemistry: 1:50~1:100
    Immunofluorescence: 1:100~1:500
  • other_names：  
  • Rho-type GTPase-activating protein 7; Deleted in liver cancer 1 protein; Dlc-1; HP protein; StAR-related lipid transfer protein 12
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total RHG07 protein.
  • Applications：  
  • IHC IF
  • Background：  
  • Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.

    Yuan B.Z., Cancer Res. 58:2196-2199(1998).
    Nagase T., DNA Res. 7:347-355(2000).
    Wilson P.J., Hum. Mutat. 15:156-165(2000).



 
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