TF2H2 Antibody

Catalog Number:

33874

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q13888
NCBI Gene ID: 2966

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from N-terminal of human TF2H2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TF2H2 protein.

Applications:

WB

Background:

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.

Humbert S., EMBO J. 13:2393-2398(1994).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
van der Steege G., Eur. J. Hum. Genet. 3:87-95(1995).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF