SRY Antibody

Catalog Number:

33859

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q05066
NCBI Gene ID: 6736

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human SRY.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SRY protein.

Applications:

WB

Background:

Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells By similarity. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons By similarity. Involved in different aspects of gene regulation including promoter activation or repression By similarity. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.

Sinclair A.H., Nature 346:240-244(1990).
Su H., Am. J. Hum. Genet. 52:24-38(1993).
Behlke M.A., Genomics 17:736-739(1993).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF