Product Datasheet  
SRY Antibody  
Catalog Number: 33859  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q05066
    NCBI Gene ID: 6736
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human SRY.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • Delayed-early protein HRS; HRS; Pre-mRNA splicing factor SRP40; SFR5; SRP40
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total SRY protein.
  • Applications：  
  • WB
  • Background：  
  • Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells By similarity. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons By similarity. Involved in different aspects of gene regulation including promoter activation or repression By similarity. Promotes DNA bending. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Also involved in pre-mRNA splicing. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'.

    Sinclair A.H., Nature 346:240-244(1990).
    Su H., Am. J. Hum. Genet. 52:24-38(1993).
    Behlke M.A., Genomics 17:736-739(1993).



 
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