p57KIP2 Antibody

Catalog Number:

33788

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P49918
NCBI Gene ID: 1028

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human p57KIP2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total p57KIP2 protein.

Applications:

IHC

Background:

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

Matsuoka S., Genes Dev. 9:650-662(1995).
Reid L.H., Cancer Res. 56:1214-1218(1996).
Tokino T., Hum. Genet. 97:625-631(1996).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF