Product Datasheet  
p57KIP2 Antibody  
Catalog Number: 33788  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P49918
    NCBI Gene ID: 1028
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human p57KIP2.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunohistochemistry: 1:50~1:100
  • other_names：  
  • CDKN1C; CDN1C; CDNC; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total p57KIP2 protein.
  • Applications：  
  • IHC
  • Background：  
  • Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

    Matsuoka S., Genes Dev. 9:650-662(1995).
    Reid L.H., Cancer Res. 56:1214-1218(1996).
    Tokino T., Hum. Genet. 97:625-631(1996).



 
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