FRK Antibody

Catalog Number:

33770

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P42685
NCBI Gene ID: 2444

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human FRK.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total FRK protein.

Applications:

WB IHC IF

Background:

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Lee J., Gene 138:247-251(1994).
Cance W.G., Cell Growth Differ. 5:1347-1355(1994).
Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005).

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Datasheet PDF