Product Datasheet  
FRK Antibody  
Catalog Number: 33770  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P42685
    NCBI Gene ID: 2444
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human FRK.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
    Immunofluorescence: 1:100~1:500
  • other_names：  
  • EC 2.7.1.112; EC 2.7.10.2; Nuclear tyrosine protein kinase RAK; Tyrosine-protein kinase FRK; fyn-related kinase
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total FRK protein.
  • Applications：  
  • WB IHC IF
  • Background：  
  • Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

    Lee J., Gene 138:247-251(1994).
    Cance W.G., Cell Growth Differ. 5:1347-1355(1994).
    Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005).



 
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