TNF Receptor II Antibody

Catalog Number:

33710

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P20333
NCBI Gene ID: 7133

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from C-terminal of human TNF Receptor II.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TNF Receptor II protein.

Applications:

WB IF

Background:

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Smith C.A., Science 248:1019-1023(1990).
Kohno T., Proc. Natl. Acad. Sci. U.S.A. 87:8331-8335(1990).
Beltinger C.P., Genomics 35:94-100(1996).

References:

appl_detail:

Western blotting: 1:500~1:3000

Immunofluorescence: 1:100~1:500

Datasheet PDF