Product Datasheet  
TNF Receptor II Antibody  
Catalog Number: 33710  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P20333
    NCBI Gene ID: 7133
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from C-terminal of human TNF Receptor II.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:3000

    Immunofluorescence: 1:100~1:500
  • other_names：  
  • Tumor necrosis factor receptor superfamily member 1B [Precursor]; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; p75
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total TNF Receptor II protein.
  • Applications：  
  • WB IF
  • Background：  
  • Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

    Smith C.A., Science 248:1019-1023(1990).
    Kohno T., Proc. Natl. Acad. Sci. U.S.A. 87:8331-8335(1990).
    Beltinger C.P., Genomics 35:94-100(1996).



 
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