ATF3 Antibody

Catalog Number:

33704

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P18847
NCBI Gene ID: 467

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human ATF3.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ATF3 protein.

Applications:

WB

Background:

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.

Chen B.P.C., J. Biol. Chem. 269:15819-15826(1994).
Hai T., Genes Dev. 3:2083-2090(1989).
Hillman R.T., Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF