Product Datasheet  
ATF3 Antibody  
Catalog Number: 33704  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P18847
    NCBI Gene ID: 467
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human ATF3.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • Cyclic AMP-dependent transcription factor ATF-3; Activating transcription factor 3; ATF3;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total ATF3 protein.
  • Applications：  
  • WB
  • Background：  
  • This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.

    Chen B.P.C., J. Biol. Chem. 269:15819-15826(1994).
    Hai T., Genes Dev. 3:2083-2090(1989).
    Hillman R.T., Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004).



 
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