Heparin Cofactor II Antibody

Catalog Number:

33652

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P05546
NCBI Gene ID: 3053

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human Heparin Cofactor II.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Heparin Cofactor II protein.

Applications:

WB

Background:

Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.

Blinder M.A., Biochemistry 27:752-759(1988).
Herzog R., Biochemistry 30:1350-1357(1991).
Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).

References:

appl_detail:

WB dilution: 1:500-1:3000

Datasheet PDF