Product Datasheet  
Heparin Cofactor II Antibody  
Catalog Number: 33652  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P05546
    NCBI Gene ID: 3053
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human Heparin Cofactor II.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • WB dilution: 1:500-1:3000
  • other_names：  
  • Heparin cofactor 2 [Precursor]; Heparin cofactor II; HC-II; Protease inhibitor leuserpin 2; HLS2
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Heparin Cofactor II protein.
  • Applications：  
  • WB
  • Background：  
  • Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.

    Blinder M.A., Biochemistry 27:752-759(1988).
    Herzog R., Biochemistry 30:1350-1357(1991).
    Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).



 
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