HES7 Antibody

Catalog Number:

33624

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O94992
NCBI Gene ID: 10614

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from Internal of human HES7.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total HES7 protein.

Applications:

WB IF

Background:

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.

Kusuhara M., Biomed. Res. 20:273-279(1999).
Wittmann B.M., Cancer Res. 63:5151-5158(2003).
Ouchida R., Genes Cells 8:95-107(2003).

References:

appl_detail:

Western blotting: 1:500~1:3000

Immunofluorescence: 1:100~1:500

Datasheet PDF