Product Datasheet  
HES7 Antibody  
Catalog Number: 33624  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: O94992
    NCBI Gene ID: 10614
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from Internal of human HES7.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000

    Immunofluorescence: 1:100~1:500
  • other_names：  
  • Protein HEXIM1; Hexamethylene bis-acetamide-inducible protein 1; Cardiac lineage protein 1; Estrogen down-regulated gene 1 protein; Menage a quatre protein 1
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total HES7 protein.
  • Applications：  
  • WB IF
  • Background：  
  • Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.

    Kusuhara M., Biomed. Res. 20:273-279(1999).
    Wittmann B.M., Cancer Res. 63:5151-5158(2003).
    Ouchida R., Genes Cells 8:95-107(2003).



 
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