SIN3B Antibody

Catalog Number:

33607

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O75182
NCBI Gene ID: 23309

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human SIN3B.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SIN3B protein.

Applications:

WB IF

Background:

Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription By similarity.

Ishikawa K., DNA Res. 5:169-176(1998).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Wysocka J., Genes Dev. 17:896-911(2003).

References:

appl_detail:

Western blotting: 1:500~1:3000

Immunofluorescence: 1:100~1:500

Datasheet PDF